What is a Myofibroma?
Myofibroma is a solitary nodular tumor of the soft tissue, bone, or internal organs that affects all ages. The tumor may present as single or multiple nodules.
What is infantile fibromatosis?
Infantile myofibromatosis, or IM, is a rare tumor that grows in the skin, muscles, bones, and sometimes in the organs of the chest or abdomen. IM tumors are benign, which means they are not cancer and do not spread to other parts of the body. But these tumors may grow large and damage nearby organs.
What causes a Myofibroma?
Most cases of infantile myofibromatosis occur randomly, for no apparent reason. Rare familial cases (in which more than one family member is affected) have been identified and genetic changes (mutations) in two different genes (PDGFRB and NOTCH3) have been found to cause the condition in most of these cases.
What is infantile fibrosarcoma?
A type of cancer that forms in fibrous (connective) tissue. Infantile fibrosarcoma usually occurs in infants and young children but it may also be found before birth by ultrasound. It can occur anywhere in the body. The tumor is often large and fast-growing, but it rarely spreads to other parts of the body.
What causes infantile Myofibromatosis?
Infantile myofibromatosis caused by mutations in the platelet-derived growth factor receptor beta (PGDFRB) gene is passed from one generation to the next following autosomal dominant mode of inheritance.
What causes infantile fibrosarcoma?
The exact cause of fibrosarcoma and other soft tissue tumors is not entirely understood. However, studies have indicated that genetic alterations may play a role. Researchers have studied a small number of families that contain several members from one generation who have developed soft tissue sarcomas.
What is Infantile myofibromatosis (im)?
Infantile myofibromatosis, or IM, is a rare tumor that grows in the skin, muscles, bones, and sometimes in the organs of the chest or abdomen. IM tumors are benign, which means they are not cancer and do not spread to other parts of the body. But these tumors may grow large and damage nearby organs.
What is myofibroma?
Myofibroma is a solitary nodular tumor of the soft tissue, bone, or internal organs that affects all ages. The tumor may present as single or multiple nodules.
What is solitary infantile myofibroma?
It is most commonly a solitary lesion arising in the first 2 years of life, when it is also called solitary infantile myofibroma. It is thought to be of myofibroblastic origin. Low power view of myofibroma demonstrates a well defined multinodular tumour arising in the deep dermis or subcutis (Figure 1).
Can myofibroma be misdiagnosed as a tumor?
Microscopically, myofibroma can be misdiagnosed with a variety of benign tumors (e.g., smooth muscle and neural tissue origin), aggressive borderline lesions (e.g., desmoplastic fibroma), and malignant spindle cell tumors (e.g., fibrosarcoma).
