What is aminophenol used for?
It is widely used in the synthesis of pharmaceuticals, dyes and other organic products and is mainly for the synthesis of paracetamol, clofibrate ketone, vitamin B1 and compound nicotinamide. It can be used as the raw material of medicine and dyes, antioxidants and the developer.
How do you synthesis paracetamol?
Synthesis of Paracetamol (Morning) Paracetamol is made by reacting 4-aminophenol with ethanoic anhydride (more commonly called acetic anhydride). This reaction forms an amide bond and ethanoic acid as a by- product. When the reaction is complete the paracetamol is then isolated and purified.
What are the functional groups in 4 aminophenol?
|CAS Number (of the unlabelled compound)||123-30-8|
|Shipping Hazards||TOXIC (PGIII)|
|Functional Groups||Alcohols & Phenols,Amines & Amine Salts|
What is aminophenol sulfate?
Sulfate is a substituted p-aminophenol, and thus data found in the reports on the aminophenols, as well as on other oxidative hair dye ingredients, such as the phenylenediamines and resorcinols, are useful in the evaluation of the safety of p-Methylaminophenol Sulfate.
What is a 4-aminophenol derivative?
The para- aminophenol derivatives include acetaminophen, and the indole acetic acid derivatives include indomethacin and etodolac. The heteroarylacetic acid derivatives are typified by diclofenac. Arylpropionic acids include ibuprofen and naproxen.
How do you extract 4-aminophenol?
4-aminophenol is isolated by vacuum filtration, rinsed twice with two 200 g aliquots of cold 1% sodium hydrosulfite solution and sucked dry on a frit for several minutes. The material (which can be acetylated at this point to make APAP) was dried at 50° C. in vacuo overnight.
How do you take 4 aminophenol?
It is produced from phenol by nitration followed by reduction with iron. Alternatively, the partial hydrogenation of nitrobenzene affords phenylhydroxylamine, which rearranges primarily to 4-aminophenol: C6H5NO2 + 2 H2 → C6H5NHOH + H2O.
How do you make paracetamol with para aminophenol?
Paracetamol is prepared from p- aminophenol by acetylating it with acetic anhydride in the presence of 3-4 drops of concentrated sulphuric acid as catalyst.
How is 4-aminophenol formed?
The best yields of 4-aminophenol are achieved by reduction of a suspension of nitrobenzene in 50% sulphuric acid at a nickel cathode in the temperature range 25–60° C when the product precipitates as the hydrogen sulphate in 65% yield .
Is 4-aminophenol a base or acid?
The amino group behaves as a weak base, giving salts with both mineral and organic acids. The aminophenols are chemically reactive, undergoing reactions involving both the aromatic amino group and the phenolic hydroxyl moiety. Aminophenol undergoes a variety of cyclization reactions.
Is 4-aminophenol water soluble?
|Solubility in water||1.5 g/100 mL|
|Solubility||Very soluble in dimethylsulfoxide Soluble in acetonitrile, ethyl acetate, and acetone Slightly soluble in toluene, diethyl ether, and ethanol Negligible solubility in benzene and chloroform|
|Acidity (pKa)||5.48 (amino; H2O) 10.30 (phenol; H2O)|
What is another accepted name for 4-aminophenol?
4-Aminophenol, also known as 4-aminobenzenol or 4-hydroxyaniline, belongs to the class of organic compounds known as aniline and substituted anilines. These are organic compounds containing an aminobenzene moiety.