Is aripiprazole soluble in water?
Aripiprazole is a white to off-white crystalline powder, freely soluble in N,N-dimethylformamide, soluble in dichloromethane, very slightly soluble in ethanol (96%). and practically insoluble in water.
Is aripiprazole hygroscopic?
The active substance is a white or almost white crystals or crystalline hygroscopic powder, practically insoluble in water, soluble in methylene chloride and very slightly soluble in ethanol (96 per cent). Its molecular weight is 448.4 g∙mol-1, corresponding to the general molecular formula C23H27Cl2N3O2.
How is aripiprazole metabolized?
Aripiprazole is metabolized primarily by three biotransformation pathways: dehydrogenation, hydroxylation, and N-dealkylation. Based on in vitro studies, CYP3A4 and CYP2D6 enzymes are responsible for dehydrogenation and hydroxylation of aripiprazole, and N-dealkylation is catalyzed by CYP3A4.
What is the pharmacological classification of aripiprazole?
Aripiprazole is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain.
Can aripiprazole be compounded?
Extemporaneously compounded oral suspensions of 1.0 mg/mL aripiprazole in 1:1 Ora-Plus and Ora-Sweet are stable for at least 91 days when stored in amber, plastic prescription bottles at 4°C, whereas suspensions in 1:1 1% methylcellulose and Simple Syrup NF are stable for up to 67 days.
What is the shelf life of aripiprazole?
Opened bottles of ABILIFY Oral Solution can be used for up to 6 months after opening, but not beyond the expiration date on the bottle. The bottle and its contents should be discarded after the expiration date.
Is Abilify metabolized by the liver?
Aripiprazole is extensively metabolized by the liver via the P450 system, largely by CYP 3A4 and 2D6 and is susceptible to drug-drug interactions with agents that induce or inhibit these microsomal enzymes.
What enzyme metabolizes Abilify?
Aripiprazole is extensively metabolized in the liver by the cytochrome P450 (CYP) superfamily of enzymes, mainly CYP2D6 and CYP3A4.
Can Abilify be crushed?
Swallow the tablets whole. Do not break, crush, or chew them. Abilify Mycite® has a sensor in the tablet, which helps track it inside the stomach or bowels.
Does aripiprazole come in liquid?
Clear, colourless liquid. Aripiprazole Oral Solution is indicated for the treatment of schizophrenia in adults and in adolescents aged 15 years and older.
What flavor is Abilify liquid?
The active substance is aripiprazole. Each mL contains 1 mg of aripiprazole. The other ingredients are disodium edetate, fructose, glycerin, lactic acid, methyl parahydroxybenzoate (E218), propylene glycol, propyl parahydroxybenzoate (E216), sodium hydroxide, sucrose, purified water, and orange flavour.
Does aripiprazole come in liquid form?
Is aripiprazole a weak alkaline drug?
Aripiprazole (ARI, Fig. S1 A), a weak alkaline drug with pH-dependent solubility in aqueous solutions ( Borbás et al., 2015, Xu et al., 2012 ), was chosen as the model drug. Since many drugs are pH-dependent, this study provides mechanistic insights on the importance of pH modifiers in the SDs in order to enhance bioavailability.
What is the solubility of Ari?
ARI, a weakly basic drug, has been known to have a pH-dependent solubility ( Mihajlovic et al., 2012 ). Preliminary studies showed that ARI had higher levels of drug solubility in more acidic environments ( Fig. S2 ). ARI was most soluble at pH values of 1.2 and 4.0 and had very low solubility in pH solutions above 6.8.
Can APZ nanosuspension prepare insoluble drugs with pH-dependent solubility?
APZ nanosuspensions got maximum absorption rate and extent comparing with APZ commercial tablet and suspensions with relative bioavailability of 123.43 ± 12.98% and 171.41 ± 14.62%, respectively. This technique has the potential to prepare nanosuspensions of insoluble drugs with pH-dependent solubility.
What patents are available for aripiprazole (Abilify)?
Patents are available for this chemical structure: N021713 (Prescription Drug: ABILIFY. Ingredients: ARIPIPRAZOLE) N021436 (Prescription Drug: ABILIFY.