What is flumazenil an antidote for?

What is flumazenil an antidote for?

Flumazenil is a selective competitive antagonist of the gamma-aminobutyric acid (GABA) receptor and is the only available specific antidote for benzodiazepine (BZD) toxicity. It will reverse the effects of BZDs but must be used with caution.

What drug class is Digibind?

Digibind belongs to a class of drugs called Antidotes, Other. It is not known if Digibind is safe and effective in children.

What drug reverses dexmedetomidine?

Atipamezole is a veterinary drug whose prime purpose is to reverse the effects of the sedative dexmedetomidine (as well as its racemic mixture, medetomidine). It can also be used to reverse the related sedative xylazine.

What is Anexate used for?

ANEXATE contains the active ingredient flumazenil. ANEXATE is used to reverse the effects of benzodiazepines, a class of anti-anxiety or sedative medicines.

In which poisoning the Digibind is used as an effective antidote?

Digibind and DigiFab are Fab fragments of antidigoxin antibody used in treating life-threatening acute digoxin overdose. Digibind was the first antidote available for treating digoxin overdose in the United States and was marketed in 1986 by Glaxo Wellcome Company.

When do you use Digibind?

Digibind is indicated for the treatment of potentially life-threatening digoxin intoxication. The manifestations of life-threatening digoxin toxicity include ventricular arrhythmias such as ventricular tachycardia or ventricular fibrillation or profound and progressive bradyarrhythmias not responsive to atropine.

Is atropine reversible or irreversible?

Muscarinic receptors have been characterized in smooth muscle and brain by the binding of reversible (e.g. atropine, quinuclidinylbenzylate) or irreversible (benzilylcholine or propylbenzilylcholine mustards) ligands.

What kind of receptor blocker is atropine?

muscarinic receptor antagonist
Atropine is a muscarinic receptor antagonist that is used to inhibit the effects of excessive vagal activation on the heart, which is manifested as sinus bradycardia and AV nodal block.

Which drug is used in acetaminophen overdose?

Oral N-Acetylcysteine The oral formulation of NAC (Mucomyst) is the drug of choice for the treatment of acetaminophen overdose.

Should Digibind be given to patients with digoxin toxicity?

there is often a reluctance to give digibind due to cost and underestimating the mortality associated with digoxin toxicity, however it is prudent to administer digibind based on a considered risk assessment and before the life-threatening manifestations of digoxin toxicity develop

What happens if you don’t use Digibind?

Digoxin toxicity resulting from overdose can be one of the most challenging overdoses the emergency practitioner may be called upon to treat. The good news is that a specific antidote, Digibind, is readily available. The bad news is that failure to use this antidote properly is common, and can result in less than acceptable outcomes if misused.

How do you administer Digibind?

Digibind is administered by intravenous injection after reconstitution with sterile water for injection (4 mL per vial). Following intravenous administration of Digibind in humans with normal renal function, the half-life of the antidote appears to be 15 to 20 hours.

What is the clinical action of Digibind?

The clinical action of Digibind reflects the fact that the affinity of Digibind for digoxin exceeds the affinity of digoxin for sodium-potassium ATPase, the receptor site for the adverse effects of digoxin in overdose.

What is Norpropoxyphene used for?

Propoxyphene is an opioid pain reliever used to treat mild to moderate pain. It is sold under various names as a single-ingredient product (e.g., Darvon) and as part of a combination product with acetaminophen (e.g., Darvocet).

Why is pethidine not given IV?

Pethidine should not be given IV as it significantly depresses myocardial contractility and causes histamine release. Vomiting is rarely seen after administration and it does not cause excitement in cats or horses.

When should you not give pethidine?

Pethidine Injection must not be used with drugs used to treat severe depression, such as rasagiline or moclobemide or if you are within 2 weeks of discontinuing them. A large number of drugs can interact with Pethidine Injection which can significantly alter their effects.

What is the antidote of atropine?

The antidote to atropine is physostigmine or pilocarpine. A common mnemonic used to describe the physiologic manifestations of atropine overdose is: “hot as a hare, blind as a bat, dry as a bone, red as a beet, and mad as a hatter”.

What is Romazicon used to reverse?

Flumazenil is used to reverse the effects of a benzodiazepine (BENZ-oh-dye-AYZ-e-peen) sedative such as Valium, Versed, Xanax, Tranxene, and others. Flumazenil is used to help you wake up after a surgery or medical procedure in which a benzodiazepine was used as a sedative.

What is the antidote for digoxin?

In the case of severe digoxin intoxication, an antidote digoxin immune Fab (Digibind) is available. Digibind binds and inactivates digoxin.

Is flumazenil a GABA antagonist?

Flumazenil is best known as a competitive antagonist at the benzodiazepine-binding site on the GABAA receptor, and has long-standing clinical use as an emergency treatment for benzodiazepine overdose.

What is placidyl used for?

Uses for Placidyl Ethchlorvynol is used to treat insomnia (trouble in sleeping). However, it has generally been replaced by other medicines for the treatment of insomnia. If ethchlorvynol is used regularly (for example, every day) to help produce sleep, it is usually not effective for more than 1 week.

What is Propacet?

ACETAMINOPHEN; PROPOXYPHENE (a set a MEE noe fen; proe POX i feen) is a pain reliever. It is used to treat mild to moderate pain. COMMON BRAND NAME(S): Balacet, Darvocet A500, Darvocet-N 100, Darvocet-N 50, Propacet.

What is the antidote for heparin?

Abstract: Heparin antidote is protamine sulphate. It is used when quick reversal of the action of heparin is needed as in case of bleeding or after an open heart surgery. Low molecular weight protamine is under development.

Is protamine sulphate a good antidote for bleeding with low molecular weight heparins?

It is generally considered that protamine sulphate is not a good antidote for bleeding with low molecular weight heparins as it cannot completely neutralize the anti factor Xa activity of low molecular weight heparins.

What happens if you give protamine sulfate after heparin?

Heparin Antidote Termination of the IV infusion generally will terminate the anticoagulant effect. If immediate reversal is required protamine sulfate will result in neutralization of heparin. The dose of protamine is based on the amount of heparin administered in the previous 2 hours using Table 2.

How do you neutralize heparin in an IV?

Termination of the IV infusion generally will terminate the anticoagulant effect. If immediate reversal is required protamine sulfate will result in neutralization of heparin. The dose of protamine is based on the amount of heparin administered in the previous 2 hours using Table 2.

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