What is IgG subclass 4 deficiency?

Isolated deficiency of IgG4 is associated with symptoms and signs which are similar to those associated with other IgG subclass deficiencies. The most common manifestation is an unusual frequency of pyogenic infections, most often of the respiratory tract.

What does it mean when IgG subclass 1 is low?

As IgG1 is the most abundant IgG subclass, its deficiency often results in hypogammaglobulinemia. IgG1 and IgG3 deficiency: People with this combination are commonly present with infections of the lower airways, which can progress to chronic lung disease.

What does it mean when IgG Subclass 2 is low?

IgG2 subclass deficiency is the most common subclass deficiency associated with recurrent infection. It may be accompanied by IgG4 deficiency, IgA deficiency, or both. Pure IgG subclass deficiency is rare in association with chronic lymphocytic leukemia.

What causes IgG subclass deficiency?

IgG subclass deficiencies are sometimes associated with poor or partial responses to pneumococcal polysaccharides, specifically IgG2 deficiency with or without IgG4 deficiency. Recently, a number of inflammatory diseases, including some forms of pancreatitis, were found to be associated with an elevated IgG4 level.

Is IgG deficiency serious?

An IgG deficiency is a health problem in which your body doesn’t make enough Immunoglobulin G (IgG). People with IgG deficiency are more likely to get infections. When your body feels it is under attack, it makes special proteins called immunoglobulins or antibodies. These antibodies are made by the plasma cells.

Is IgG deficiency an autoimmune disease?

Patients with primary or secondary IgG subclass deficiencies suffer from infections due to encapsulated microorganisms such as H influenzae and pneumococci. In addition to relapsing infections, some patients with primary subclass deficiencies may have autoimmune disorders.

Can low IgG cause fatigue?

Fatigue Is Common in Immunoglobulin G Subclass Deficiency and Correlates With Inflammatory Response and Need for Immunoglobulin Replacement Therapy. Purpose: Individuals with immunoglobulin G deficiency (IgGsd) often complain of fatigue.

How serious is IgG deficiency?

People with IgG deficiency are more likely to get infections. Although researchers don’t know what causes primary IgG deficiency, genetics may play a role. When the symptoms come on later in life, the health problems may be more difficult to manage, and you may have more infections.

Can low IgG levels cause fatigue?

What medications can cause IgG deficiency?

Secondary IgG deficiency may be caused by: Aging. Malnutrition. Chemotherapy medicines and long-term corticosteroids.

What are the causes of low IgG and IgM?

Low IgG and IgM levels occur with some forms of leukemia, notes WebMD. Low IgG levels alone may occur with macroglobulinemia, a disease that happens when high levels of IgM stop the production of IgG antibodies. Low IgM levels may occur in those diagnosed with multiple myeloma.

What is the treatment for IgG deficiency?

IgA deficient patients with recurrent infections to determine if there is an associated IgG2 and IgG4 subclass deficiency

What are normal levels of IgG?

IGG : The gamma globulin band as seen in conventional serum protein electrophoresis consists of 5 immunoglobulins. In normal serum, about 80% is immunoglobulin G (IgG). Elevations of IgG may be due to polyclonal immunoglobulin production. Monoclonal elevations of IgG characterize multiple myeloma. Monoclonal gammopathies of all types may lead to a spike in the gamma globulin zone seen on serum

What causes low IgA levels?

Low levels The most common causes of decreased immunoglobulins are acquired underlying (secondary) conditions that either affect the body’s ability to produce immunoglobulins or that increase the loss of protein from the body. Deficiencies may also be due to drugs such as immunosuppressants, corticosteroids, phenytoin, and carbamazepine or due