What is the function of miR 7?
MiR-7 plays an important role in suppressing the migration, colony formation, and cell-cycle progression of lung cancer cells. Reducing the amount of miR-7 can promote the growth and metastasis of human lung carcinoma A549 and H1299 cells significantly .
What is miR 181a?
In this study, we report that microRNA (miR)-181a is a negative regulator of nuclear factor κ–light-chain enhancer of activated B-cells (NF-κB) signaling. miR-181a overexpression significantly decreases the expression and activity of key NF-κB signaling components.
What is a miR mimic?
miRNA mimics are innovative molecules designed for gene silencing approaches. miRNA mimics contain nonnatural or artificial double stranded miRNA-like RNA fragments. These RNA fragments are constructed to contain a sequence motif on its 5′-end that is partially complementary to the target sequence in the 3’UTR.
What is miRNA sponge?
The microRNA (miRNA) “sponge” method was introduced three years ago as a means to create continuous miRNA loss of function in cell lines and transgenic organisms. Sponge RNAs contain complementary binding sites to a miRNA of interest, and are produced from transgenes within cells.
Is miR-214 high in cancer?
Plasma microRNA 214 (miR-214) expression is significantly higher in gastric cancer (GC) patients than in normal individuals. GC patients with high miR-214 expression are likely to have larger tumors, lymphatic metastasis, larger TNM stage, and higher carcinoembryonic antigen and carbohydrate antigen 19-9 levels.
How does ankylosing spondylitis affect miR-214 levels?
Lower expression of serum miR-214 occurs in ankylosing spondylitis. Overexpression of miR-214 or knockdown of the novel miR-214 targets, ANKRD6 or CTBP1, increased melanoma cell proliferation, migration, and decreased sensitivity to MAPKi.
Is miR-214 an adjunct therapy in breast cancer harboring wild type p53?
FOXD3/miR-214/MED19 axis is important for the regulation of growth, invasion and metastasis of colorectal cancer In conclusion, miR-214 functions as a tumor suppressor by regulating the RFWD2-p53 cascade, thus delivery of miR-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53.
Is mir-214-3p a valuable biomarker for sinonasal inverted papilloma?
MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for sinonasal inverted papilloma (SNIP). Plasma microRNA 214 (miR-214) expression is significantly higher in gastric cancer (GC) patients than in normal individuals.