What does connexin 26 do?

What does connexin 26 do?

Connexin 26 is a member of the connexin protein family. Connexin proteins form channels called gap junctions that permit the transport of nutrients, charged atoms (ions), and signaling molecules between adjoining cells.

What chromosome is GJB2 on?

The GJB2 gene is located on chromosome 13q12 and it encodes the connexin 26, a transmembrane protein involved in cell-cell attachment of almost all tissues. GJB2 mutations cause autosomal recessive (DFNB1) and sometimes dominant (DFNA3) non-syndromic sensorineural hearing loss.

What are connexins used for?

Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells.

Where are connexins found?

Connexins have been found in the nucleus, where they may function as transcription factors, and at the mitochondrial membrane, where they may function in bcl-2 activation and apoptosis.

How much does a cx26c excavator weigh?

The 5,520 lb., Tier 4 Final CX26C provides excellent breakout force in a lightweight, zero tailswing excavator that achieves dig depths of nearly 8 feet. This compact, transport-friendly power makes this mini ideal for landscapers, utility companies and contractors working in developed neighborhoods or trying to minimize yard damage.

Is Cx26 a tumor suppressor or a gene Suppressor?

Down-regulation of the gap junction protein connexin26 (Cx26) is an early event following breast cancer onset and has led to Cx26 being classically described as a tumor suppressor. Interestingly, mutations in theCx26 gene (GJB2) reduce or ablate Cx26 gap junction channel function and are the most common cause of genetic deafness.

What can the cx26c do for You?

With standard push blade, auxiliary hydraulics and proportional controls, as well as an available heated cab, the CX26C is a multi-use platform for a wide variety of applications and environments.

How fuel-efficient is the Mazda cx-26c?

The CX26C features a fuel-efficient, naturally aspirated 25-hp engine, providing excellent power and performance with minimal fuel use while meeting Tier 4 Final regulations without any operator inconvenience.

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