What do Rosenthal fibers do?
Abstract. Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous mutations in the GFAP gene, encoding glial fibrillary acidic protein (GFAP).
What are Rosenthal fibers made of?
In summary, Rosenthal fibers are intracellular inclusions found in fibrous astrocytes and represent fragments of GFAP, the protein building block of glial intermediate filaments, and other proteins such as ubiquitin and heat shock proteins.
Which tumor exhibits Rosenthal fibers?
Its presence is associated with either pilocytic astrocytoma (more common) or Alexander’s disease (a rare leukodystrophy). They are also seen in the context of fucosidosis. Pilocytic astrocytoma is the most common primitive tumor found in pediatrics.
What is the contribution of Rosenthal?
Professor Rosenthal has also made significant contributions to the area of sources of artifact in behavioral research and in various quantitative procedures. In the realm of data analysis, his special interests are in experimental design and analysis, contrast analysis, and meta-analysis.
What does Pilocytic mean?
Listen to pronunciation. (PY-loh-SIH-tik) Made up of cells that look like fibers when viewed under a microscope.
What does Rosenthal mean?
rose valley
Rosenthal Name Meaning German: habitational name from any of numerous places named Rosenthal or Rosendahl (‘rose valley’). Jewish (Ashkenazic): ornamental name from the German compound Rosenthal ‘rose valley’.
Who is Rosenthal?
Rosenthal GmbH is a German manufacturer of porcelain products and other household goods. The original firm was founded in 1879 in Selb, Bavaria. Since 2009, Rosenthal has been owned by the Italian company Sambonet Paderno Industrie (Arcturus Group).
Why is it called pilocytic?
In children, the condition may be called juvenile pilocytic astrocytoma. Pilocytic astrocytoma gets its name because the tumor originates from star-shaped cells in the brain called astrocytes. Astrocytes are glial cells, which help to protect and sustain brain cells called neurons.
What is Rosenthal fiber?
Rosenthal fiber. A Rosenthal fiber is a thick, elongated, worm-like or “corkscrew” eosinophilic (pink) bundle that is found on H&E staining of the brain in the presence of long-standing gliosis, occasional tumors, and some metabolic disorders.
What are Rosenthal fibers in astrocytes?
In summary, Rosenthal fibers are intracellular inclusions found in fibrous astrocytes and represent fragments of GFAP, the protein building block of glial intermediate filaments, and other proteins such as ubiquitin and heat shock proteins. Rosenthal fibers are observed in Alexander disease and certain tumors such as pilocytic astrocytoma.
What is the difference between Rosenthal fibers and granular bodies?
Most PAs harbor Rosenthal fibers within their compact or fibrillary areas. Eosinophilic granular bodies may also be present but are often fewer than Rosenthal fibers (Figure 2a-2d). PMAs lack Rosenthal fibers and a biphasic pattern and exceptionally demonstrate rare eosinophilic granular bodies.
What causes Rosenthal fibers in cysts?
Rosenthal fibers are also known to occur in the walls of some cysts. The irritation of the cyst protein possibly causes a stress reaction in the astrocytes that in turn results in upregulation of GFAP with possible assembly or degradation issues that lead to abnormal variants of GFAP and production of Rosenthal fibers.
