What is collagenase clostridium histolyticum used for?
Collagenase clostridium histolyticum injection is used to treat Dupuytren’s contracture with a palpable cord. It is also used to treat Peyronie’s disease with a palpable plaque and curvature deformity in men.
What is the most common side effect after a single collagenase treatment?
The most frequently reported adverse drug reactions (≥25%) in the XIAFLEX clinical trials in patients with Peyronie’s disease were penile hematoma, penile swelling, and penile pain.
Are collagenase injections painful?
Conclusions: Collagenase Clostridium histolyticum injection for treating Dupuytren contracture can be a painful process.
How painful are Xiaflex injections?
Pain. Although Xiaflex is not uncomfortable to receive, some patients have significant pain for up to 48 hours after the injection, with rare patients having discomfort beyond this period. Verapamil is more painful to receive, likely due to the volume of fluid, but is not significantly painful thereafter.
What is clostridial collagenase ointment?
Clostridial collagenase ointment (CCO) is currently the only enzymatic debriding ointment that has US FDA approval and has been used as a method of wound debridement for more than 50 years .
What are the side effects of Xiaflex?
Common Xiaflex side effects may include:
- swelling, bruising, bleeding, pain, or tenderness where the medicine was injected;
- swollen glands in your elbow or underarm;
- itching, redness, or warmth of the skin;
- cracked skin;
- underarm pain;
- mild pain or tenderness in your treated hand;
Why is XIAFLEX no longer available in Canada?
Dear Healthcare Professional: We are writing to inform you that Paladin will discontinue the commercialization of XIAFLEX® (collagenase clostridium histolyticum) in Canada as of June 30, 2020. The decision to withdraw is not based on safety or efficacy concerns.
How successful is XIAFLEX?
Studies have shown 34% improvement in penile curvature in men who underwent treatment with Xiaflex injection compared to 18% improvement in men treated with saline injection. In a study of 832 men, three men had penile fracture.
What causes Peyronie’s disease?
Peyronie’s disease is likely caused by minor injury to the penis. (See penile trauma.) This type of damage is most often caused by vigorous sex (such as bending the penis during penetration or pressure from a partner’s pubic bone), though it can also be caused by sports or other accidents.
How long does it take to recover from XIAFLEX injection?
“It took me several weeks to recover from the incisions followed by thirty physical therapy sessions after each surgery. With Xiaflex, the recuperative process took only two weeks, and I was back to normal.”
How much do xiaflex injections cost?
Xiaflex costs $3,300 an injection, so a full course of eight injections would cost about $26,000, in addition to a doctor’s fee. Doctors already use less expensive drugs off-label to treat Peyronies, including injections of a generic blood pressure drug.
How successful is xiaflex?
What is Collagenase clostridium histolyticum injection used for?
Collagenase Clostridium histolyticum injection is also used to treat Peyronie’s disease (a thickening of tissue [plaque] inside the penis that causes the penis to curve).
How is Collagenase clostridium histolyticum administered for Peyronie’s disease?
If you are receiving treatment for Peyronie’s disease, your doctor will inject collagenase Clostridium histolyticum into your penis, followed by a second injection 1 to 3 days after the first injection You must return to your doctor’s office 1 to 3 days after your second injection.
How is Collagenase clostridium histolyticum administered for Dupuytren’s contracture?
If you are receiving collagenase Clostridium histolyticum to treat Dupuytren’s contracture, your doctor will inject the medicine into a cord just under the skin in the affected hand.
What is the generic name for Collagenase clostridium histo?
GENERIC NAME(S): Collagenase Clostridium Histo. WARNINGS: When used to treat a certain penis condition (Peyronie’s disease), this drug has rarely caused very serious injury to the penis (such as penile fracture/hematoma).